Small ship line Cruise West announced it would launch its first sailings on the Mississippi, Ohio and Tennessee rivers starting in March 2011.
The seven-night voyage includes a stop at the famed Oak Alley Plantation, picturesque Natchez, Mississippi; and Vicksburg National Military Park.
The Seattle-based line -- a major player in small ship cruising in Alaska -- says it plans two itineraries on the Middle America rivers aboard the 102-passenger Spirit of America, which until now has been known as the Spirit of Glacier Bay.
The era of overnight cruises on the Mississippi, Ohio and Tennessee rivers seemingly came to an end in 2008 with the demise of the Majestic America Line, but now it looks like it's making a comeback.
One of the two new Cruise West itineraries will focus on the "iconic South" on the Mississippi River from New Orleans to Memphis, with visits to Southern mansions, gardens, historic plantations, and Civil War monuments.